He was born in Sliema on the 22 November 1935. As a young adult, he bought the bookshop in central Valletta from his father following a failed attempt to sell the shop to Mabel Strickland. He ran Sapienza's until 1985 when a company was formed that is now run by his sons James, Mark and Brian.
Louis Sapienza was affectionately known as a humane, religious and humble entrepreneur who always considered his clients as friends. Throughout his life, he refrained from involvement in political or civil associations with the exception of GRUFAN, a discussion group set up by Fr. Hilary Tagliaferro in which he participated in recent years.
He died on 26 May 2005 at the age of 69.