The singing career of Cherylis went back to 2000. She take part in many festivals like Għaqda fil-Melodija, Għanja tal-Maltin, When she got a beautiful experiances when she, participated in a trio group Unison composer with her and Albertine Abela and Matthias Brancaleone and they placed first in an important festival named as L-Għanja tal-Maltin with the song Waqtiet.
On 2010 she went rapprezenting Malta in the International Nile Song Festival with a great success.
Cherylis learn also the piano from 1998 with the London College of Music. Form 1994 she was also involved in dram since 1994 when she act in several Musicals Malti Ghost Busters, Sms mingħand Ġesu', Sms mingħand Ġesu 2, San Sebastjan, San Ġorg Fjur u l-Martri, Grease, San Leonardu, Mosè u l-għaxar Kmandamenti, Rex Ideorum and Ġensna in Concert.
Cherylis as an actress taken part in the the Maltee dramaseriel D.R.E.A.M.S where also interpreted the main part. Cherylis where on many television programs as well as 5 years ago she took part in the Junior Eurosong 2009 with the song Hey Yo.
Cherylis were winners of Konkors Kanzunetta Indipendenża - Talent Żagħżugħ (2010) with the song Nemmen Fik.
Recently she also went represent Malta in Romania at the festival inside Steaua Carpatilor gaining 3rd place from contestant 36 and took special prize and in 2013 she also achieved 3rd place in Estonia in Gold Leaf Festival.
On June 2014 she also went represent Malta at Maori in Italy which also has been successful. Cherylis Camilleri is also one of the semi finalists in the Konkors Kanzunetta Indipendenza 2014 with the song Ħolma ta’ Nazzjon composed by Marco Debono and lyrics by Rita Pace.
In September 2014 Cherylis took part and ended among the finalists in the final night of the Konkors Kanzunetta Indipendenza , with the song Ħolma ta’ Nazzjon lyrics by Rita Pace and music by Marco Debono.With this song also won the prize of Third place.
In July 2016 Cherylis took part for the first time in the L-Għanja tal-Poplu 2016 – (Festival Kanzunetta Maltija) with the song Is-Sinjur lyricis by Emil Calleja Bayliss and composed by Mark Scicluna. She passed from the Semi-Finali held on Thursday 7 July, 2016 he passed for the Final Night held on Saturday 9 July, 2016 with this song.
Late in 2015, Cherylis and Mikhail Attard embarked on a new project, that entitled Dwett. They have reached the second phase of the Malta Eurovision Song Contest with the song Breaking Point, before reaching the final of the Konkors Kanzunetta Indipendenza 2016 with the song Bit-Tikketta.
On 31 August, 2019 Cherylis was one of the finalist of the 43 Edition of L-Għanja tal-Poplu 2019 – Festival tal-Kanzunetta Maltija with the song ‘Tfewwaħ’ words and music by herself and with it win the Second place beside she got the singersongwriter price.
On 19 September, 2019 Cherylis was one of the finalist in the 28 Edition of Konkors Kanzunetta Indipendenza 2019 held at Pieta near Dar Ċentrali with the song 'Wirt Tfuliti' lyrics by Emil Calleja Bayliss and music by Philip Vella.
On Thursday 26 August, 2021, made it to the final of Konkors Kanzunetta Indipendenza 2021 Cherylis performed the song Nifs lyrics by Emil Calleja Bayliss and music by Philip Vella. On the final night held on 18 September, 2021, at she performed the song Nifs lyrics by Emil Calleja Bayliss and music by Philip Vella and she win the first place and win Konkors Kanzunetta Indipendenza 2021.
|2018||Malta Eurovision Song Contest 2018||Breaking Point||Dwett||Muxu Matt Mercieca||Elton Zarb|
|2017||Is-Sinjur||Emil Calleja Bayliss||Mark Scicluna||(Click for Video)|